Bilastine vs. hydroxyzine: occupation of brain histamine H-1-receptors evaluated by positron emission tomography in healthy volunteers

摘要

AimA close correlation exists between positron emission tomography (PET)-determined histamine H-1-receptor occupancy (H1RO) and the incidence of sedation. Antihistamines with H1RO <20% are classified as non-sedating. The objective was to compare the H1RO of bilastine, a second generation antihistamine, with that of hydroxyzine.