Identifying 24h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach

Kervezee Laura; Stevens Jasper; Birkhoff Willem; Kamerling Ingrid M. C.; de Boer Theo; Droge Melloney; Meijer Johanna H.; Burggraaf Jacobus

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Identifying 24h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach

机译：确定左氧氟沙星药代动力学的24小时变化：一种群体药代动力学方法

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摘要

AimThe objective of this study was to investigate whether the pharmacokinetics of orally administered levofloxacin show 24h variation. Levofloxacin was used as a model compound for solubility and permeability independent absorption and passive renal elimination.

机译：目的本研究的目的是研究口服左氧氟沙星的药代动力学是否表现出24h变化。左氧氟沙星用作溶解度和渗透性独立吸收以及被动消除肾脏的模型化合物。

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《British Journal of Clinical Pharmacology》 |2016年第2期|共13页
作者
Kervezee Laura; Stevens Jasper; Birkhoff Willem; Kamerling Ingrid M. C.; de Boer Theo; Droge Melloney; Meijer Johanna H.; Burggraaf Jacobus;
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正文语种 eng
中图分类药理学;
关键词
chronopharmacokinetics; diurnal variation; fluoroquinolone; population pharmacokinetic modelling; time of administration;

机译：时间药代动力学;日变化;氟喹诺酮;种群药代动力学模型;给药时间;
入库时间 2022-08-18 09:14:15

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专利

1. Identifying 24h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach [J] . Kervezee Laura, Stevens Jasper, Birkhoff Willem, British Journal of Clinical Pharmacology . 2016,第2期

机译：确定左氧氟沙星药代动力学的24小时变化：一种群体药代动力学方法
2. Identifying factors affecting the pharmacokinetics of voriconazole in patients with liver dysfunction: A population pharmacokinetic approach [J] . Tang Dan, Song Bai-Li, Yan Miao, Basic & clinical pharmacology & toxicology. . 2019,第S1期

机译：鉴定影响患有肝功能障碍患者伏立康唑的药代动力学的因素：人口药代动力学方法
3. Identifying factors affecting the pharmacokinetics of voriconazole in patients with liver dysfunction: A population pharmacokinetic approach [J] . Tang Dan, Song Bai‐Li, Yan Miao, Basic & clinical pharmacology & toxicology. . 2019,第1期

机译：鉴定影响患有肝功能障碍患者伏立康唑的药代动力学的因素：人口药代动力学方法
4. Nonparametric identification of population pharmacokinetic models: An MCMC approach [C] . Marta Neve, Giuseppe De Nicolao, Laura Marches American Control Conference . 2005

机译：人口药代动力学模型的非参数鉴定：MCMC方法
5. Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach. [D] . Chung, Eun Kyoung. 2015

机译：使用群体药代动力学/药效学方法，与非肥胖患者相比，肥胖患者的β-内酰胺抗菌药物剂量优化。
6. Identifying 24 h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach [O] . Laura Kervezee, Jasper Stevens, Willem Birkhoff, 2016

机译：确定左氧氟沙星药代动力学的24小时变化：群体药代动力学方法
7. Population Pharmacokinetic Model Characterizing 24‐Hour Variation in the Pharmacokinetics of Oral and Intravenous Midazolam in Healthy Volunteers [O] . A van Rongen, L Kervezee, MJE Brill, 2015

机译：人口药代动力学模型表征健康志愿者口腔和静脉内嗜含量的药代动力学24小时变异

Identifying 24h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach

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