The obesity epidemic (with the associated co-morbidities) poses a major health-care challenge for the 21st Century [1]. A 'Westernised' lifestyle (calorie dense diets and reduced physical activity) fuel this epidemic, on the background of genetic susceptibility [2,3].Therapeutic options for clinically significant weight-loss and weight-loss maintenance are currently limited. Whilst appropriate public-health measures need instigated to reduce the obese burden, the development of new anti-obesity agents is much awaited.
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