Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects

Boyce Malcolm; Dowen Sally; Turnbull Gillian; van den Berg Frans; Zhao Chun-Mei; Chen Duan; Black James

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Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects

机译：奈曲肽，胃泌素/ CCK2受体拮抗剂，对健康受试者胃酸分泌和雷贝拉唑引起的高胃泌素血症的影响

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AimsTo compare gastric acid suppression by netazepide, a gastrin/CCK2 receptor antagonist, with that by a proton pump inhibitor (PPI), and to determine if netazepide can prevent the trophic effects of PPI-induced hypergastrinaemia.

机译：目的比较胃泌素/ CCK2受体拮抗剂奈那肽与质子泵抑制剂（PPI）对胃酸的抑制作用，并确定奈那肽是否可以预防PPI引起的高胃泌素血症的营养作用。

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《British Journal of Clinical Pharmacology》 |2015年第5期|共12页
作者
Boyce Malcolm; Dowen Sally; Turnbull Gillian; van den Berg Frans; Zhao Chun-Mei; Chen Duan; Black James;
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正文语种 eng
中图分类药理学;
关键词
chromogranin A; gastric acid; gastrin; CCK2 receptor antagonist; hypergastrinaemia; netazepide; rabeprazole;

机译：嗜铬粒蛋白A;胃酸;胃泌素;CCK2受体拮抗剂;高胃泌素血症;奈那肽;雷贝拉唑;

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1. Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects [J] . Boyce Malcolm, Dowen Sally, Turnbull Gillian, British Journal of Clinical Pharmacology . 2015,第5期

机译：奈曲肽，胃泌素/ CCK2受体拮抗剂，对健康受试者胃酸分泌和雷贝拉唑引起的高胃泌素血症的影响
2. Effect of repeated doses of netazepide, a gastrin receptor antagonist, omeprazole and placebo on 24?h gastric acidity and gastrin in healthy subjects [J] . Boyce Malcolm, Warrington Steve British journal of clinical pharmacology . 2013,第5期

机译：反复服用奈他肽，胃泌素受体拮抗剂，奥美拉唑和安慰剂对健康受试者24小时胃酸度和胃泌素的影响
3. Netazepide, a gastrin/CCK2 receptor antagonist, causes dose‐dependent, persistent inhibition of the responses to pentagastrin in healthy subjects [J] . Boyce Malcolm, Warrington Steve, Black James British journal of clinical pharmacology . 2013,第5期

机译：Netazepide是一种胃泌素/ CCK2受体拮抗剂，导致剂量依赖，对健康受试者对彭代杀蛋白的反应抑制
4. Prostaglandin El and a Serine Protease inhibitor Protect the Gastric Microcirculation and Increase the Gastric Acid Secretion After Thermal Injury [C] . Tetsuya Nakamuea, Masashi Yoshida, Hideki Ishikawa, Keio International Symposia for Life Sciences and Medicine . 2005

机译：前列腺素el和丝氨酸蛋白酶抑制剂保护胃微循环，并在热损伤后增加胃酸分泌物
5. Investigation of the roles of gastrin and histamine in gastric acid secretion using genetically engineered mouse models. [D] . Hinkle, Karen Lynn. 2002

机译：使用基因工程小鼠模型研究胃泌素和组胺在胃酸分泌中的作用。
6. Effect of netazepide a gastrin/CCK2 receptor antagonist on gastric acid secretion and rabeprazoleinduced hypergastrinaemia in healthy subjects [O] . Malcolm Boyce, Sally Dowen, Gillian Turnbull, 2015

机译：奈曲肽胃泌素/ CCK2受体拮抗剂对健康受试者胃酸分泌和雷贝拉唑引起的高胃泌素血症的影响
7. Effect of repeated doses of netazepide, a gastrin receptor antagonist, omeprazole and placebo on 24 h gastric acidity and gastrin in healthy subjects [O] . Malcolm Boyce, Steve Warrington 2013

机译：重复剂量的Netazepide，胃泌素受体拮抗剂，Omeprazole和安慰剂对健康受试者24小时胃酸和胃泌素的影响

Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects

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