Comparative performance of oral midazolam clearance and plasma 4-hydroxycholesterol to explain interindividual variability in tacrolimus clearance

摘要

AimsWe compared the CYP3A4 metrics weight-corrected midazolam apparent oral clearance (MDZ Cl/F/W) and plasma 4-hydroxycholesterol/cholesterol (4-OHC/C) as they relate to tacrolimus (TAC) Cl/F/W in renal transplant recipients.