Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period

Dong Min; Fukuda Tsuyoshi; Cox Shareen; de Vries Marij T.; Hooper David K.; Goebel Jens; Vinks Alexander A.

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Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period

机译：移植后早期儿科肾移植受者中麦考酚酸的群体药代动力学模型

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AimThe purpose of this study was to develop a population pharmacokinetic and pharmacodynamic (PK-PD) model for mycophenolic acid (MPA) in paediatric renal transplant recipients in the early post-transplant period.

机译：目的本研究的目的是在移植后早期为儿童肾移植接受者建立麦考酚酸（MPA）的群体药代动力学和药效学（PK-PD）模型。

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来源
《British Journal of Clinical Pharmacology》 |2014年第5期|共11页
作者
Dong Min; Fukuda Tsuyoshi; Cox Shareen; de Vries Marij T.; Hooper David K.; Goebel Jens; Vinks Alexander A.;
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正文语种 eng
中图分类药理学;
关键词
inosine monophosphate dehydrogenase (IMPDH); mycophenolic acid; paediatric patient; pharmacodynamics; pharmacokinetics; transit absorption model;

机译：肌苷一磷酸脱氢酶（IMPDH）;麦考酚酸;儿科病人;药效学;药代动力学;转运吸收模型;

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1. Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period [J] . Dong Min, Fukuda Tsuyoshi, Cox Shareen, British Journal of Clinical Pharmacology . 2014,第5期

机译：移植后早期儿科肾移植受者中麦考酚酸的群体药代动力学模型
2. Limited sampling strategy of mycophenolic acid in adult kidney transplant recipients: Influence of the post-transplant period and the pharmacokinetic profile [J] . ChaabaneA., AouamK., FredjN.B., The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2013,第9期

机译：成年肾移植受者中麦考酚酸的有限采样策略：移植后时期和药代动力学特征的影响
3. Limited Sampling Strategy for Estimating Mycophenolic Acid Exposure on Day 7 Post-Transplant for Two Mycophenolate Mofetil Formulations Derived From 20 Chinese Renal Transplant Recipients [J] . Cai W., Cai Q., Xiong N., Transplantation Proceedings . 2018,第5期

机译：用于估算霉菌酸暴露的有限抽样策略，用于衍生自20例肾移植受者的两次霉酚酸酯制剂后第7天移植后移植后
4. Using OCT to Predict Post-Transplant Renal Function [C] . Peter M Andrews, Yu Chen, Jeremiah Wierwille, Conference on photonic therapeutics and diagnostics IX . 2013

机译：使用OCT预测移植后肾功能
5. Mycophenolic acid versus azathioprine in primary immunosuppression for kidney transplant recipients - Systematic review, meta-analysis, and meta-regression. [D] . Wagner, Martin. 2009

机译：麦考酚酸与硫唑嘌呤在肾移植受者初次免疫抑制中的作用-系统评价，荟萃分析和荟萃回归。
6. Population pharmacokinetic–pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period [O] . Min Dong, Tsuyoshi Fukuda, Shareen Cox, 2014

机译：移植后早期儿童肾脏移植受者中麦考酚酸的群体药代动力学-药效学模拟
7. Explaining variability in mycophenolic acid exposure to optimize mycophenolate mofetil dosing: a population pharmacokinetic meta-analysis of mycophenolic acid in renal transplant recipients [O] . van Hest, Reinier M., Mathot, Ron A. A., Pescovitz, Mark D., 2006

机译：解释麦考酚酸暴露的变异性以优化麦考酚酸酯的剂量：肾移植受者中麦考酚酸的群体药代动力学荟萃分析

Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period

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