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GiANT: gene set uncertainty in enrichment analysis

机译:GiANT:富集分析中的基因集不确定性

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摘要

Over the past years growing knowledge about biological processes and pathways revealed complex interaction networks involving many genes. In order to understand these networks, analysis of differential expression has continuously moved from single genes towards the study of gene sets. Various approaches for the assessment of gene sets have been developed in the context of gene set analysis (GSA). These approaches are bridging the gap between raw measurements and semantically meaningful terms.
机译:在过去的几年中,有关生物过程和途径的知识不断增长,揭示了涉及许多基因的复杂相互作用网络。为了理解这些网络,差异表达的分析已从单一基因不断地发展到基因集的研究。在基因组分析(GSA)的背景下,已经开发了各种评估基因组的方法。这些方法弥合了原始度量和语义上有意义的术语之间的鸿沟。

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