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Don't use a cannon to kill the ... miRNA mosquito.

机译:不要使用大炮杀死... miRNA蚊子。

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Supervised machine-learning approaches are frequently applied on biological data to learn a regression or classification model, whether used for prediction, classification or for gaining an understanding on the biological process that has generated the data (Larranaga et al., 2006). Arguably however, it is sometimes the case that sophisticated and complicated methods are employed, published and advocated as advances without a comparison even against the simplest baseline methods. We consider a baseline method as the simplest method that an expert analyst can conceive within a few minutes of consideration of the problem and does not require any engineering or scientific ingenuity or novelty. A baseline can take the form of comparing against predicting by the mean of the outcome on a known dataset, without use of any special predicting variables, or comparing against random guessing. Because of this lack of comparison, the added-value of the sophisticated methods—if any—is not quantified; it remains unknown whether the extra effort for implementing or applying it is worth. A false perception about the difficulty of the problem may be created.
机译:有监督的机器学习方法经常应用于生物数据,以学习回归模型或分类模型,无论是用于预测,分类还是用于了解已生成数据的生物过程(Larranaga等,2006)。然而,可以说有时有时会采用先进的,复杂的方法作为先进技术来发布,宣传和倡导,甚至无法与最简单的基准方法进行比较。我们认为基准方法是专家分析人员在考虑问题后几分钟内可以想到的最简单方法,不需要任何工程或科学知识或新颖性。基线可以采用在不使用任何特殊预测变量的情况下通过已知数据集上的结果均值与预测值进行比较或与随机猜测进行比较的形式。由于缺乏比较,无法量化复杂方法的附加值(如果有)。实施或应用它的额外努力是否值得仍然未知。可能会产生对问题难度的错误认识。

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