首页> 外文期刊>Bioinformatics >A global pathway crosstalk network.
【24h】

A global pathway crosstalk network.

机译:全球路径串扰网络。

获取原文
获取原文并翻译 | 示例
           

摘要

Given the complex nature of biological systems, pathways often need to function in a coordinated fashion in order to produce appropriate physiological responses to both internal and external stimuli. Therefore, understanding the interaction and crosstalk between pathways is important for understanding the function of both cells and more complex systems. RESULTS: We have developed a computational approach to detect crosstalk among pathways based on protein interactions between the pathway components. We built a global mammalian pathway crosstalk network that includes 580 pathways (covering 4753 genes) with 1815 edges between pathways. This crosstalk network follows a power-law distribution: P(k) approximately k(-)(gamma), gamma = 1.45, where P(k) is the number of pathways with k neighbors, thus pathway interactions may exhibit the same scale-free phenomenon that has been documented for protein interaction networks. We further used this network to understand colorectal cancer progression to metastasis based on transcriptomic data. CONTACT: yong.2.li@gsk.com SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
机译:考虑到生物系统的复杂性,通路通常需要以协调的方式起作用,以便对内部和外部刺激产生适当的生理反应。因此,了解通路之间的相互作用和串扰对理解细胞和更复杂系统的功能很重要。结果:我们已经开发了一种基于途径组分之间蛋白质相互作用检测途径之间串扰的计算方法。我们建立了一个全球哺乳动物通路串扰网络,其中包括580条通路(覆盖4753个基因),通路之间有1815条边。此串扰网络遵循幂律分布:P(k)大约为k(-)(γ),γ= 1.45,其中P(k)是具有k个邻居的路径数,因此路径相互作用可能表现出相同的尺度-已针对蛋白质相互作用网络记录了自由现象。我们进一步使用该网络基于转录组数据了解大肠癌向转移的进展。联系人:yong.2.li@gsk.com补充信息:补充数据可从在线生物信息学获得。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号