SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks

摘要

SUMMARY: SpotXplore is a plugin for Cytoscape for extraction and visualization of differentially expressed subnetworks (hotspots) from gene networks. The hotspot-based visualization approach enables interactive exploration of regulatory interactions in differentially expressed gene sets, and it allows a researcher to explore gene expression in direct relation to the affected cellular gene network. The hotspots provide a view beyond the commonly used metabolic pathways and gene ontologies. AVAILABILITY: http://www.win.tue.nl/6mwestenb/spotxplore/ CONTACT: m.a.westenbergue.nl Supplementary information: Example data and user manual are available at SpotXplore's web site.