Synthesis and Bioactivity of Novel Adamantyl Derivatives as Potent MDR Reversal Agents

摘要

Multidrug Resistance (MDR) is a type of resistance of tumor cells to various kinds of chemotherapeutic drugs which are structurally unrelated and also one of the major impediments to chemotherapeutic treatment of cancer. It has been reported that 49 ATP-binding cassette (ABC) transporter genes are present in the human genome. Among them, over-expression of P-glycoprotein (P-gp), encoded by MDR1 gene is one of the major factors contributing to multidrug resistance which leads to barrier to successful chemotherapy.