Fluorescence Study Gives a Hint to Understand How the p53 DNA Binding Domain Recognizes Its Specific Binding Site on DNA Fragments

摘要

The p53 protein, which is known as the tumor suppressor protein, displays various cellular functions such as regulating the expression of diverse downstream genes, apoptosis, cell cycle arrest, DNA repair, cell differentiation, and other related functions through binding sequence specifically to the target DNA. Mutation of the p53 protein has been reported to be strongly implicated in cancers. Therefore studies on p53 look important to understand the mechanism of inducing cancer. The cellular levels of p53 are strictly controlled, and the activity of p53 is regulated post-trans-lational modification in vivo.