Copper/l-proline-catalyzed synthesis of 5-amino-2,3-diphenylimidazo2,1-aisoquinolines in the presence of Cs2CO3

摘要

Malononitrile underwent -arylation with 2-(2-bromophenyl)-4,5-diphenyl-1H-imidazole to give a subsequent nucleophilic addition and dehydration products of 5-amino-2,3-diphenylimidazo2,1-aisoquinoline-6-carbonitriles catalyzed by CuI/l-proline. Under the same reaction conditions, this novel procedure had a good chemoselectivity in cyanacetates for the efficient synthesis of 5-aminoimidazo2,1-aisoquinoline-6-carboxylate derivatives in good yields.