Alternative models for QTL detection in livestock. III. Heteroskedastic model and models corresponding to several distributions of the QTL effect

摘要

Alternative models for quantitative trait locus (QTL) detection in livestock are described: a heteroskedastic model, and models corresponding to several hypotheses concerning the distribution of the QTL substitution effect among the sires: a fixed and limited number of alleles or an infinite number of alleles. The power of tests incorporating these hypotheses under different situations was calculated. Genetic variance associated with the QTL was observed in some situations. It is concluded that there are small power differences between the different models, but important differences in the quality of the estimations. A model was produced for a simplified situation to investigate the gain when possible linkage disequilibrium is incorporated.