Clinical image. Middle interhemispheric variant of holoprosencephaly.

摘要

A girl was born at gestational week 34 from a pregnancy complicated by pre-eclampsia and insulin-dependent diabetes mellitus. Multiple fetal anomalies were found on US (holoprosencephaly, cardiac situs inversus, ventricular septal defect and polyhydramnios). Fetal (Fig. 1) and postnatal (Fig. 2) brain MRIs show midline fusion of posterior frontal and anterior parietal regions with callosal dysgenesis and lack of midline thalamic fusion.