Synthesis of an Unnatural Steroid as a Farnesoid X Receptor Antagonist

摘要

Bile acids are major products of hepatic cholesterol catabolism and are natural ligands for the Farnesoid X receptor (FXR). These acids play critical roles in the regulation of intestinal lipid absorption, bile flow, and biliary lipid secretion. FXR, also called the bile acid receptor (BAR), is a member of the nuclear receptor superfamily, which includes ligand-modulated transcription factors and is involved in cholesterol homeostasis in mammals.