Anti-resorptive and Anabolic Activity of 3-(3,5-Dimethoxyphenyl)-6-methoxybenzofuran-4-carboxylate

摘要

Bone remodeling is sustained by the balance between the osteoclast-mediated bone resorption and the osteoblast-mediated bone formation. Old bone is resorbed by matured osteoclasts that are derived from hematopoietic stem cells of the monocyte/macrophage lineage by the receptor activator of NF-kB ligand (RANKL) and then the resorbed area is newly filled with new bone matrix that is synthesized by osteoblasts. Osteoblast-mediated bone formation is also the highly regulated and sequential process. Mesenchymal stem cells (MSCs) initially commit to pre-osteoblasts by bone morphogenetic proteins (BMPs) and subsequently those are matured into osteoblasts, the essential for bone mineralization.