Synthesis of Dimers of (4-Oxo-4H-pyran-2-yl)acrylic Acid as Tyrosinase Inhibitors

摘要

Tyrosinase (EC 1.14.18.1) is a copper-containing enzyme which catalyzes two distinct reactions in the biosynthesis of melanin; the hydroxylation of L-tyrosine to L-dopa and the oxidation of L-dopa to dopaquinone. The dopaquinone is highly reactive and can polymerize spontaneously to form melanin in a series of reaction pathway. Therefore, the regulation of melanin synthesis via the inhibition of tyrosinase has been recent subject of many studies to prevent hyperpigmentation.