A Simple and Convenient Synthesis of (±)-Methylcyclopentanone-3-carboxylate; an Important Precursor of Antitumor Drug Sarkomycin

摘要

Umezawa et al. isolated the natural product sarkomycin, a cyclopentanoid antibiotic from the soil microorganism, Strep-tomyces erythrochromogenes in 1953. Until 1960's, sarkomycin has been used as a prescription drug against cancer in Russia, Japan and USA due to its strong inhibitory effect on several human tumors including Yoshida sarcoma, Sarcoma-180 and Hela carcinoma.