New Rancinamycin Analogues from Streptomyces lincolnensis

摘要

Streptomyces is the largest bacterial genus with antibiotic secondary metabolites. It is also the source of immunosuppressants, anti-cancer, and anti-hyperlipidemic lead compounds. Streptomyces lincolnensis produces lincomycin and related antibiotics. Rancinamycins I-IV and gamma-aminobutyric acid (GABA) as antibiotics and a growth related factor, respectively, were also reported from S. lincolnensis. As part of an ongoing search for antioxidant compounds from S. lincolnensis, proto-catechualdehyde was isolated from a butanol fraction of the extract. In a continuing study on the same strain, two new cyclitol derivatives, which are designated lincitols A and B, along with a benzaldehyde derivative were isolated from the butanol fraction (Figure 1). This paper describes the isolation, structure elucidation, and biological evaluation of the isolated compounds.