Enantioselective Conjugate Addition of Fluoromalonate to Nitroalkenes Catalyzed by Chiral Nickel Complexes

摘要

Fluorinated compounds are of importance in organic synthesis because of their use as medicines and agrochemicals and in fundamental studies of biochemical and metabolic processes. Introduction of fluorine atom into biologically active compounds often leads to improvement of their biological characteristics due to unique properties of the fluorine atom. Chiral organofluorine compounds have been utilized in studies of enzyme mechanisms and as intermediates in asymmetric syntheses.