Anti-Helicobacter pylori Activity and Structure-Activity Relationships of Berberine Derivatives

摘要

In 1983, Warren and Marshall found that gastritis and most stomach ulcers are caused by Helicobacter pylori infection, and not by stress or spicy food, as had been previously assumed. This bacteria is known to produce a toxin that may be potentiated by ammonia generated from urease. Since that time, many types of anti-H pylori agents focusing on inhibition of H. pylori growth and/or anti-urease activity have been chemically synthesized or isolated from natural sources for treatment of patients with gastroduodenal disorders.