A Fluorescence 'Turn-On' Microfluidic Sensor Based on an Acenaphthopyrrolcarbonitrile Derivative

摘要

The design and synthesis for a selective and sensitive fluorescent sensor has been the central focus of recent investigation.In general,for sensor applications,it is more desirable to have the system generate a fluorescence signal(i.e.,turn-on type)rather than experience a loss or a decrease of fluorescence(i.e.,turn-off type)when the background fluorescence signal prior to stimulation is negligible.In this regard,8-oxo-8H-acenaphtho[1,2-b]pyrrol-9-carbonitrile(APC),a flat and highly electron-deficient heteroaromatic compound,is very attractive.APC is virtually nonfluore-scent and displays strong fluorescence upon formation of covalent adducts with certain amine or thiol compounds due to their strong intramolecular charge transfer(ICT)nature(Figure 1).This intriguing fluorogenic property of APC has been elegantly applied to the detection of amino acid,cysteine in MeOH.