HT-Sample Preparation Techniques for Bioanalysis: Microextraction by Packed Sorbent (MEPS) and Monolithic Packed Tips for 96-Well Plates

摘要

The purpose of sample preparation is the removal of interfering substances and also enrichment of the analytes. The procedure must be highly reproducible with a high recovery of the target analytes. Further, an ideal sample preparation method should involve a minimum number of working steps and it should be fully automated. Because of the low concentration levels of drug in plasma and the variety of the metabolites, the selected extraction technique should be virtually exhaustive.