Regulation of Vaccinia H1-related (VHR) Phosphatase Activity by NSC-87877

摘要

Based on amino-acid sequences of catalytic domains, protein tyrosine phosphatases (PTPs) can be classified into four groups; class I Cys-based PTPs, class II Cys-based PTPs, class III Cys-based PTPs, and Asp-based PTPs. Each PTP has a characteristic role in a variety of cellular processes including cellular metabolism, growth, proliferation, differentiation and also has been emerged as a therapeutic target in many diseases such as diabetes, leukemia, neurodegradation, and cancer.