Bromination/Hydrolytic Fragmentation Reactions of α,β-Unsaturated N-Boc Lactams for the Synthesis of ω-Amino-trisubstituted (E)-Vinyl Bromides

摘要

Trisubstituted (E)-halo alkenes are important synthetic building blocks frequently employed in the synthesis of many natural products including scyphostatin, octalactin, phomactins, borrelidin, apoptolidin, FK901464, phorboxazole A, fo-striecin, taxifolial A, kendomycin, tedanolide and deoxy-tedanolide.