Preparation of Naproxen-Loaded Poly(ethyIene oxide-b-methacrylic acid) Micelleand Its pH-dependent Drug Release Behavior

摘要

To achieve effective targeted delivery and satisfactory therapeutic applications,various synthetic polymers have been used for the delivery of therapeutic agents such as drugs and genes. Among synthetic polymers,arnphiphilic polymers are self-assembled in aqueous solution to minimize contact between water and hydrophobic blocks,and they can contain hydrophobic drugs in the inner hydrophobic core. Recently,the biological signals-responsive smart micelles are reported for the selective release of drug at target organs.