Azetidine-based Anthracenyl Chemosensor for Cu(II) Ion in Aqueous Media

摘要

Environmental poisoning by heavy metals, such as Hg~(2+), Pb~(2+), and Cu~(2+), has been increased in the last three decades due to extensive use of them in agricultural, chemical and industrial processes, which are becoming threats to living organisms. Particularly, Cu(IT) is an essential element playing a fundamental role in the biochemistry of the human nervous system, but its high concentration is toxic. Thus, its accumulation in the human body affects a wide variety of disease, such as Menkes disease, Wilson's disease and Alzheimer's disease. Therefore, in recent years, many efforts have been made to develop various chemosensors specifically for the Cu~(2+) ion detection. Chang et al. reported BODIPY (borondipyrromethene) having thioether receptor for selective and stable binding towards Cu~(2+) in water. Kraemer et al. developed fluorescein-Cu~(2+) quencher pairs in molecular beacon oligonucleotide. Czarnik et al. exploited rhodamine B hydrazide based on hydrolysis in the presence of Cu~(2+)ion.