New 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one Derivative Has Both Tyrosinase Inhibitory and Antioxidant Properties

摘要

Kojic acid,5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one,is produced from carbohydrate sources in an aerobic process by a variety of microorganisms.It showed broad biological activities such as inhibition of tyrosinase,scavenging of the free radicals,chelating activity of metal ions4 and prevention of photodamage.Its various activities are due to gamma-pyranone structure having enolic hydroxy 1 group.Recently,enolic hydroxyl group of kojic acid has been focused as an alternative of carboxylic acid in retinoid structure.We synthesized 3,4-methylenedioxy cinnamic acid ester of kojic acid as a new retinoidal compound.In this study,we evaluated biological activities of new kojic acid derivative 1,2-((3E)-4(2H,3H-benzo[3,4-d]l,3-dioxolan-5-yl)-2-oxo-but-3-enyloxy)-5-hydroxy-4H-pyran-4-one.