Site-Specific Phosphorylation Profiling: Ti-Tyr Chips Deliver Quantitative Analyses of Cell-Signaling Network Dynamics

摘要

Site-specific tyrosyl phosphorylation is a key mediator of intracellular communication and represents a rapid readout of the cell-signaling network's response to drugs or other stimuli. For this reason, proteins involved in these signaling responses have become major targets for therapeutic intervention. The complexity of these responses, however, requires powerful tools that can monitor information flow through the signaling network and identify important biomarkers associated with disease or drug responses.