Staying Ahead of Upstream Developments: New Solutions Focus on Relieving Pressure on Downstream Operations

摘要

The whole value chain, from cell culture and upstream processing to formulation and drug delivery, was the focus of Informa's "BioProcess International" conference held recently in Vienna. A major theme of the meeting was how developments in upstreamprocessing such as cell-line improvement have led to high titers of product, which have resulted in extended pressure on downstream operations. "A big revolution is taking place—we can now increase the number of investigations in downstream processing,"said Manuel Nyffeler, program director of life sciences at GE Healthcare (www.gehealth care.com). The company advocates high-throughput process development (HTPD), which can cut down the time needed for downstream process development by up to 80%, according to Nyffeler.