Induced Pluripotent Stem Cell Overview: Review of Opportunities and Challenges in this Rapidly Expanding Field of Study

摘要

The ability to reprogram somatic cells to generate induced pluripotent stem (iPS) cells has generated tremendous interest and discussion since iPS cells were first produced from mouse cells in 2006 and human cells in 2007. The reversion of differentiated cells to a state resembling embryonic stem cells offers a wealth of opportunities for disease researchers. Interest in iPS cells is expanding rapidly beyond the domain of stem cell experts to researchers modeling complex diseases in vitro and pursuing novel therapeutics.