Wet SiO2 As a Suitable Reduction of Carbonyl Compounds with NaBH3CN under So1yent-Free and Acid-Free Conditions

摘要

Reduction of carbonyl compounds such as aldehydes, ketones α,β-unsaturated enals and enones,α-diketones andacyloins was carried out readily with NaBH3CN in the presence of wet SiO2 as a neutral wereperformed at solvent-free conditions in oil bath (70 - 80℃ ) or under microwave irradiation (240 W)to give the product alcohols in high to excellent yields. Regioselective 1,2-reduction of conjugated carbonyl compounds took place in a perfect selectivity without any side product formation.