A Mild, Efficient and Eco-friendly Synthesis of 1,3-Bis(4-arylthiazol-2-yl)benzenes in PEG-400

摘要

The thiazole ring is an important framework present in a large variety of natural products. Also this moiety is a popular building block for the construction of pharmaceutically interest compounds and has attracted attention of synthetic chemists for over a century. Substitution at the C(2) and C(4) are very frequent and, in some cases, biological activity studies have shown a relationship between the biological activity and the aromatic rings present in those positions. Among them, 2,4-diarylthiazoles are versatile building blocks which potentially have novel therapeutic activities. Within this context, recent efforts towards the synthesis of a subclass with many highly active compounds, including 2,4-thiazolylbenzenesulphon-amides (Figure 1) with potent matrix metalloproteinases (MMPs) inhibitors have been reported.