Catalytic Asymmetric Electnophilic α-Amination of β-Ketoesters in the Presence of Chiral Nickel Complexes

摘要

Amino acids are used as pharmaceuticals, agrochemicals, and fundamental synthetic building blocks for preparation of an assortment of biologically valuable molecules. The development of stereoselective synthetic methods for the preparation of natural and non-natural α-amino acid derivatives has attracted considerable attention over the past decades.