Protective Effects of Carnosine and Anserine on Oxidative Modification of Neurofilament-L Induced by Catechol Neurotoxin, Tetrahydropapaveroline

摘要

Tetrahydropapaveroline [THP; 6,7-dihydroxy-1-(3,4-di-hydroxybezyl)-1,2,3,4-terra-hydroisoquinoline)], a metabolite of dopamine, was implicated in the development of Parkinsons disease (PD) and some side effects derived from its treatment with L-dopa. Previous studies indicated that THP was toxic to dopaminergic neurons both in vitro and in vivo conditions, which suggested that THP-induced apoptosis was directly related to the potential oxidative stress caused by the oxidation of the catechol moiety of THP. Recent report also revealed that THP autoxidation occurred with a continuous generation of reactive oxygen species (ROS).