A Convenient, Eco-friendly, and Efficient Method for Synthesis of 3,3'-Arylmethylene-bis-4-hydroxycoumarins'On-water'

摘要

Coumarins, an important group of oxygen heterocycles, well known both naturally and synthetically, are used as additives to foods and cosmetics and optical brightening agents. 4-Hydroxycoumarin and its derivatives are known for their anticoagulant, antibacterial, antifungal, antibiotic, antitumor and anti-HTV activities. They are also used as agrochemicals and analytical reagents. Biscoumarins (3), the bridge substituted dimers of 4-hydroxycoumarin, have enormous potential as anticoagulants and antioxidants and some of them have also been found to be urease inhibitors. It may be mentioned here that 3,3'-methylene-bis-4-hydroxycoumarin, commonly known as dicoumarol, occurs naturally in moldy clover. It is the hemorrhagic agent responsible for the sweet clover disease of cattle and has also been employed for the prevention and treatment of thrombosis.