Synthesis and Sequence-selective Peptide-binding Properties of a C2-symmetric Metallomacrocycle

摘要

The development of synthetic receptors having selective binding properties with a variety of molecules has been an area of active research in recent years.For effective recognition,a receptor must have the preorganized binding site having the shape and functionalities to complement with those of a given substrate.So far,the greatest difficulty in making such receptors is the multistep organic synthesis needed to create structurally distinct macrocyclic molecules.