Ester Derivatives from Tannase-treated Prunioside A and Their Anti-inflammatory Activities

摘要

Prunioside A,isolated from the methanol extract of Spiraea prunifolia var.Simpliciflora's root,is composed of coumaroyl,monoterpene-type,and glucosyl units.The esterase activity of tannase was used to remove the p-coumaroyl and glucopyranosyl groups.The enzymatically hydrolyzed compound was reacted with various acyl chlorides to synthesize its ester derivatives,which showed the inhibitory effects on NO production in murine machrophage-like RAW 264.7 cells stimulated with hpopolysaccharide and interferon-gamma.