Resolution of Three Important pi-Basic Chiral Compounds on Recently Developed Five pi-Acidic Chiral Columns

摘要

The separation of chiral compounds is very important in various fields, There are many uses for optically pure chiral compounds, for example, chiral catalysts for asymmetric synthesis, chiral derivatizing agents for diastereomeric resolution, or good chiral selectors for direct chiral separation. 1,1'-Bi-2-naphthol (BNO), 1,1-binaphthyl-2,2'-diamine (BNA), and 2,2,2-trifluoro-1-(9-anthryl)ethanol (TFAE) are very popular chiral compounds used for the above purposes and their optically pure form are needed and used worldwide. Five Pirkle-type pi-acidic chiral stationary phases (CSP 1-5, Figure 1) were recently prepared with the testing data of N-acyl-1-naphthylaminoalkanes. CSP 1-3 are aminoalcohol derived CSPs while CSP 4 and 5 are amino acid derived ones, however, only a few applications of their use have been reported until now.