Complexation between Venlafaxine Hydrochloride and beta-Cyclodextrin:Structural Study by Nuclear Magnetic Resonance Spectroscopy

摘要

A detailed spectroscopic study(~1H NMR,COSY,ROESY)of complexation of venlafaxine hydrochloride(VEN)with beta-cyclodextrin(beta-CD)was earned out in solution.The stoichiometry of the complex was determined to be 1:1 and penetration of aromatic ring into beta-Cyclodextrin cavity was confirmed from primary rim side,with the help of ROESY spectral data.The structure of the venlafaxine hydrochloride-beta-CD complex has been proposed.The association constant was determined to be 234 M~(-1).