Quantitative Determination of Nicotine in a PDMS Microfluidic Channel Using Surface Enhanced Raman Spectroscopy

摘要

Rapid and highly sensitive determination of nicotine in a PDMS microfluidic channel was investigated using surface enhanced Raman spectroscopy (SERS).A three-dimensional PDMS microfluidic channel was fabricated for this purpose.This channel shows a high mixing efficiency because the transverse and vertical dispersions of the fluid occur simultaneously through the upper and lower zig zag-type blocks.A higher efficiency of mixing could also be obtained by splitting each of the confluent streams into two sub-streams that then joined and recombined.The SERS signal was measured after nicotine molecules were effectively adsorbed onto silver nanoparticles by passing through the three-dimensional channel.A quantitative analysis of nicotine was performed based on the measured peak area at 1030 cm~(-1).The detection limit was estimated to be below 0.1 ppm.In this work,the SERS detection,in combination with a PDMS microfluidic channel,has been applied to the quantitative analysis of nicotine in aqueous solution.Compared to the other conventional analytical methods,the detection sensitivity was enhanced up to several orders of magnitude.