Synthesis of Isochroman and Tetrahydroisoquinoline Derivatives from Baylis-Hillman Adducts by Radical Cyclization

摘要

Recently we were interested in radical cyclizations of modified Bayhs-Hillman adducts.We reported the synthesis of various heterocyclic compounds including 2,3-dihydrobenzofuran derivatives using radical cyclization process.Meantime we reasoned that six-membered heterocyclic compounds such as isochroman and tetrahydroisoquinoline derivatives could be prepared by radical cyclization from suitably modified Baylis-Hillman adducts (vide infra,Scheme 1).