Asymmetric Alkylation Reactions Using Non-Cross-Linked Polystyrene-supported 2-Imidazolidinone Chiral Auxiliary Derived from l-Phenyl Alanine

摘要

The non-cross-linked polystyrene (NCPS)-supported 2-imidazolidinone chiral auxiliary, based on a new anchoring strategy, afforded excellent diastereocontrol and yield in asymmetric alkylation reactions. The cleavage of this soluble, polymer-supported chiral auxiliary 8 produced highly optical pure carboxylic acids and strong polymer recovery.