Design,Synthesis and Biological Activity of Certain 3,4-Disubstituted-5-mercapto-l,2,4-triazoles and Their Hydrazine Derivatives

摘要

3-Aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-mercapto-l,2,4-triazoles (3_(a1-a14)) were prepared starting from potassium dithio carbazinates (2_(a1-a14)).These triazoles were then employed in the synthesis of 3-aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-hydrazino-l,2,4-triazoles (4_(a1-a14)).All the newly synthesized compounds were characterized by analytical,IR,NMR spectral studies.The compounds were screened for their antibacterial,antifungal,anti-inflammatory and analgesic properties.Most of the compounds have shown significant antifungal activity while few have shown excellent anti-inflammatory and analgesic activity.An attempt is made to study the structure activity relationship (SAR).