Copy-Number Methods Dramatically Underestimate Loss of Heterozygosity in Cancer

摘要

In the first seven months of 2006, Genes, Chromosomes and Cancer published eight studies using comparative genomic hybridization (CGH) to analyze genomic gains and losses in cancer (Aarts et al., 2006; Coe et al., 2006; Diep et al., 2006; Horsley et al., 2006; Hosoya et al., 2006; Mendrzyk et al., 2006; Ribeiro et al., 2006; Rossi et al., 2006)