Design, Synthesis, and Evaluation of 2-Anilino-4-(3,5-dicarboxamidespiperidine)-pyrimidines as Anaplastic Lymphoma Kinase Inhibitors

Latif Muhammad; Park Sangjun; Ali Imran; Choe Hyeonjeong; Chae Chong Hak; Park Chi Hoon; Kim Hyoung Rae; Yun Chang-Soo; Lee Kwangho

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Design, Synthesis, and Evaluation of 2-Anilino-4-(3,5-dicarboxamidespiperidine)-pyrimidines as Anaplastic Lymphoma Kinase Inhibitors

机译：设计，合成和评估的2-Anilino-4-（3,5-diarboxamidespiperidine）-嘧啶作为间变性淋巴瘤激酶抑制剂。

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来源
《Bulletin of the Korean Chemical Society》 |2015年第9期|共4页
作者
Latif Muhammad; Park Sangjun; Ali Imran; Choe Hyeonjeong; Chae Chong Hak; Park Chi Hoon; Kim Hyoung Rae; Yun Chang-Soo; Lee Kwangho;
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正文语种 eng
中图分类化学;
关键词
Anaplastic lymphoma kinase; ALK inhibitor; Pyrimidine derivatives; Kinase inhibitor; Anticancer agent;

机译：间变性间变性淋巴瘤激酶;ALK抑制剂;嘧啶衍生物;激酶抑制剂;抗癌药;

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1. Design, Synthesis, and Evaluation of 2-Anilino-4-(3,5-dicarboxamidespiperidine)-pyrimidines as Anaplastic Lymphoma Kinase Inhibitors [J] . Latif Muhammad, Park Sangjun, Ali Imran, Bulletin of the Korean Chemical Society . 2015,第9期

机译：设计，合成和评估的2-Anilino-4-（3,5-diarboxamidespiperidine）-嘧啶作为间变性淋巴瘤激酶抑制剂。
2. Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors [J] . Zhang Peilong, Dong Jiaqiang, Zhong Boyu, Bioorganic and Medicinal Chemistry Letters . 2016,第8期

机译：新型3-磺酰基吡唑-4-氨基嘧啶类化合物作为强力间变性淋巴瘤激酶（ALK）抑制剂的设计与合成
3. Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors [J] . TardyS., OrsatoA., MologniL., Bioorganic and medicinal chemistry . 2014,第4期

机译：间变性淋巴瘤激酶抑制剂苯并[4,5]咪唑并[1,2-c]嘧啶和苯并[4,5]咪唑并[1,2-a]吡嗪衍生物的合成及生物学评价
4. Selective tyrosine kinase inhibitor, STI571, inhibitsgrowth of p53 mutant anaplastic thyroid cancer cellsby inducing S-G2 transition arrest [C] . Alexei P. Podtcheko, Satoshi Tsuda, Akira Ohtsuru International Consortium for Medical Care of Hibakusha and Radiation Life Science . 2003

机译：选择性酪氨酸激酶抑制剂，STI571，P53突变体的抑制性诱导S-G2过渡逮捕的抑制性甲状腺癌细胞
5. Design, synthesis & evaluation of human Aurora kinase and phosphodiesterase inhibitors for anti-trypanosomal drug discovery via target repurposing. [D] . Ochiana, Stefan O. 2013

机译：设计，合成和评估人Aurora激酶和磷酸二酯酶抑制剂，通过靶标重新定位来抗锥虫药物。
6. Design synthesis and biological evaluation of novel 2-phenyl pyrimidine derivatives as potent Brutons tyrosine kinase (BTK) inhibitors [O] . Xinyu Li, Binyu Shi, Yu Teng, 2019

机译：新型2-苯基嘧啶衍生物作为有效的布鲁顿酪氨酸激酶（BTK）抑制剂的设计合成和生物学评估
7. Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors [O] . Deng, Xianming, Wang, Jinhua, Zhang, Jianming, 2011

机译：3,5-二氨基-1,2,4-三唑尿素作为有效的间变性淋巴瘤激酶抑制剂的发现

Design, Synthesis, and Evaluation of 2-Anilino-4-(3,5-dicarboxamidespiperidine)-pyrimidines as Anaplastic Lymphoma Kinase Inhibitors

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