Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

摘要

Background: In studies of development and aging, the expression of many genes has been shown to undergo drastic changes at mRNA and protein levels. The connection between mRNA and protein expression level changes, as well as the role of posttranscriptional regulation in controlling expression level changes in postnatal development and aging, remains largely unexplored.