Concise Asymmetric Formal Synthesis of Pyrrolopiperazinone Natural Products by Tandem Cross Metathesis/Intramolecular Aza-Conjugate Addition

摘要

With the advent of air-stable, commercially available, and functional group-tolerable ruthenium-carbene catalysts, olefin metathesis has become a powerful tool for carbon-carbon double bond formations, with various applications reported over the past decade. Meanwhile, tandem reactions, which involve ruthenium-catalyzed olefin metathesis followed by other transformations, have also been reported, giving non-metathetic products.