NSC-87877 Inhibits Cell Growth by Suppressing ERK Signaling

摘要

Reversible phosphorylation of proteins on tyrosine residues is controlled through the actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Phosphorylation and dephosphorylation of proteins is a key event in signalings that are involved in the control of cell growth, di- fferentiation, adhesion, and death. PTPs can be grouped into four classes: the classical receptor PTPs (RPTPs), the classical non-receptor PTP (nrPTPs), the dual-specificity phosphatases (DUSPs) and the low Mr PTPs.